MAO-B Inhibitors

Monoamine Oxidase Type B (MAO-B) is an enzyme in our body that breaks  down brain chemicals such as dopamine. MAO-B inhibitors block the effect of MAO-B to improve many motor symptoms of PD. MAO-B inhibitors are commonly used in early therapy or in addition to other medications to help reduce "off" time and extend "on time." Some studies indicate that MAO-B inhibitors slow the progress of PD by offering neuroprotection. MAO-B inhibitors are used to treat:

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• Slowness

• Stiffness

• Tremor

• "On/Off" fluctuations

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The most common side effects of MAO-B inhibitors include:

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• Mild nausea

• Dry mouth

• Lightheadedness

• Constipation

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Pharmacists routinely warn about other drug interactions with MAO-B inhibitors, including antidepressants. Prior to starting any MAO-B inhibitor, carefully review all medications, including over the counter medications with your physician for possible adverse reactions. It is also very important to provide information about MAO-B inhibitors to anesthesiologists prior to any surgeries.