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First Drug Approved for Dyskinesia in Parkinson’s Disease

By Kristen Teesdale

Adamas Pharmaceuticals yesterday announced U.S. Food and Drug Administration (FDA) approval of an extended-release formulation of amantadine (GOCOVRI) to treat dyskinesia in Parkinson’s disease (PD). This is the first drug indicated specifically for dyskinesia — uncontrolled, involuntary movements that can develop with long-term levodopa use.

Extended-release amantadine is intended to be taken once daily at bedtime. In this way it can control dyskinesia during the day, when it typically is most prevalent. The new therapy’s approval is based on data from three placebo-controlled trials that demonstrated safety and efficacy. In addition to easing dyskinesia, the drug also may lessen total daily “off” time, when Parkinson’s symptoms return because medication is not working optimally.

The Michael J. Fox Foundation (MJFF) helped move this drug to market by supporting the creation and authentication of the Unified Dyskinesia Rating Scale, a tool that was used to measure the drug’s impact in trials.

“Dyskinesia can significantly compromise quality of life for people with Parkinson’s,” says Todd Sherer, MJFF CEO. “We are pleased that patients have another option to manage this aspect of the disease and glad the Unified Dyskinesia Rating Scale — a tool our support helped develop and validate — could show clinical efficacy of GOCOVRI for the treatment of dyskinesia.”

Extended-release amantadine is a reformulation of a currently available generic immediate-release version, which is approved to treat Parkinson’s symptoms. (Read more about this and other medications for Parkinson’s disease.)

Read more about extended-release amantadine.

Register for Fox Trial Finder to participate in dyskinesia and other studies to advance PD understandings and therapies.

Source: Fox Feed Blog

Find a Potion for Parkinson’s

PAA is thrilled to be a part of the Find a Potion for Parkinson’s event – a 10K/5K and 1 mile fun run/walk from our friends in Jasper on Halloween morning. All proceeds benefit Parkinson’s disease research and we can’t wait to see you there!

Location: Jasper, Alabama (Gamble Park) 10K/5K starts at 9:00 – Fun run/walk starts at 8:30

  • Please click this link to download an entry form
  • Entry Fee: 10K: $30 5K: $25 Fun Run: $15 Due by Friday, October 16th.
  • If you sign-up by October 16th, you are guaranteed a t-shirt.
  • After October 16th through day of race, entry fees are: 10K: $35, 5K: $30, Fun run: $20
  • T-shirts are not guaranteed after October 16th. We will order a few extra, but they will be issued first come, first serve.
  • There will be a Packet Pick up (Bibb and shirt) at Inspire Fitness (511 19th ST West) Friday, October 30th from 4pm-6pm. If you can’t make the pickup, you may pick your packet up the day of the run at 7am.
  • If you plan to register for the run on October 31st, please be at Gamble at 7am. Registration will close at 7:45 AM.
  • Minimal age for the 10k/5k portion is 14, with parental consent.
  • There will be a costume contest. The judging will be held prior to the 10k/5k at 8:00.
  • Costumes are optional. Please, NO scary costumes! We want happy , wacky, silly or heroic costumes. You will be disqualified for scary costumes.
  • Categories for Costume Contest: Team/Group and Kids Individual
  • All participants in the 10k and 5k will receive “Finisher Medals.”
  • Trophies will be awarded at the end of the race for the top 3 male and top 3 female runners who participated in the 10K and 5K.
  • Please click this link to download an entry form
Birmingham Symposium

2015 Birmingham Symposium: Living Your Best Life with Parkinson’s Disease

The Parkinson Association of Alabama (PAA) is thrilled to host its annual Birmingham Symposium on Saturday, June 13 at the Embassy Suites in Hoover from 8:00 AM to 1:00 PM. Register online now!

Check-in and Breakfast are from 8:00 – 8:30 AM. The program is from 8:45 AM – 1:00 PM and includes a boxed lunch. Admission is free with registration, but donations are appreciated and may be submitted online or at the event. Space is limited, so we do encourage everyone interested in attending to register online.

The theme for this years forum is Living Your Best Life with Parkinson’s and we encourage anyone affected by PD to attend. Whether you’re a PD patient, caregiver, medical professionalthought leader, or simply want know more – the Birmingham Symposium offers something for everyone.

Contact the PAA Executive Director, Mary T Miller, for more information.

 

The Case For A National System Protecting Research Subjects

By Jean Burns

Can you imagine facing experimental brain surgery knowing that if you had a stroke on the table, your family’s only recourse to get Long term care for you would be to sue the federal gov’t?  I know how it feels. I took that risk.

I hope you will read this article about my participation in a recent NIH Bioethics Grand Round:

http://nihrecord.nih.gov/newsletters/2015/02_27_2015/story1.htm

Don’t humans who volunteer for risky clinical trials deserve a safety net? Isn’t it time for change? If the research community that experiments on human beings is unwilling to care for those whom they may damage during research, why should humans continue to volunteer? (and by the way, I DO believe in fairness & justice.) Can we start making noise about this problem? I need your help. ALL  human clinical trial participants need your help.