First Drug Approved for Dyskinesia in Parkinson’s Disease

By Kristen Teesdale

Adamas Pharmaceuticals yesterday announced U.S. Food and Drug Administration (FDA) approval of an extended-release formulation of amantadine (GOCOVRI) to treat dyskinesia in Parkinson’s disease (PD). This is the first drug indicated specifically for dyskinesia — uncontrolled, involuntary movements that can develop with long-term levodopa use.

Extended-release amantadine is intended to be taken once daily at bedtime. In this way it can control dyskinesia during the day, when it typically is most prevalent. The new therapy’s approval is based on data from three placebo-controlled trials that demonstrated safety and efficacy. In addition to easing dyskinesia, the drug also may lessen total daily “off” time, when Parkinson’s symptoms return because medication is not working optimally.

The Michael J. Fox Foundation (MJFF) helped move this drug to market by supporting the creation and authentication of the Unified Dyskinesia Rating Scale, a tool that was used to measure the drug’s impact in trials.

“Dyskinesia can significantly compromise quality of life for people with Parkinson’s,” says Todd Sherer, MJFF CEO. “We are pleased that patients have another option to manage this aspect of the disease and glad the Unified Dyskinesia Rating Scale — a tool our support helped develop and validate — could show clinical efficacy of GOCOVRI for the treatment of dyskinesia.”

Extended-release amantadine is a reformulation of a currently available generic immediate-release version, which is approved to treat Parkinson’s symptoms. (Read more about this and other medications for Parkinson’s disease.)

Read more about extended-release amantadine.

Register for Fox Trial Finder to participate in dyskinesia and other studies to advance PD understandings and therapies.

Source: Fox Feed Blog

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LA Support Group Shaking Up Parkinson’s Disease

PAA is thrilled to highlight a new support group called Shaking up LA (Lower Alabama). Lead by John Carmichael, this support group serves the Flomaton, Bay Minette, and Atmore area’s of Alabama. The first meeting of Shaking up LA is September 9th at 9:00 AM from the Atmore Community Hospital Auditorium. This meeting is open to all Parkinson’s fighters, caregivers, medical professionals, or anyone else interested in PD therapy, nursing, education, fitness, or other workshops. This inaugural meeting will include a short meet-and-greet and planning session with light refreshment. For more information about the Shaking up LA support group, please contact John Carmichael at  carmicje14@gmail.com or shakinguploweralabama@gmail.com

Though their first meeting is still a couple weeks away, Shaking up LA is already raising PD awareness and funds through a unique t-shirt design that captures the spirit of confronting PD progression in a truly creative and meaningful way. PAA is honored to be a beneficiary of funds raised through these great shirts and we hope you’ll grab a couple for yourself! Please see below for style, size, and ordering details!

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In 2000, Eminem recorded “The Real Slim Shady” with the lyrics “won’t the real Slim Shady please stand up.” In the spirit of those shirts, the Real Slim Shaky shirts have been designed by Denny Giles at ShalloWit Design for the Parkinson’s support group, Shaking Up LA (Lower Alabama), as a fundraising shirt for the The Parkinson Association of Alabama, and to shed light on Parkinson’s disease by encouraging serious conversations about support and resources for PD fighters and their caregivers.

  • As a PD fighter, these shirts encourage us to “stand up” as the Real Slim Shaky and live like a warrior each day, realizing each day is a new fight, and that we have the opportunity to shake up the world where we live in spite of Parkinson’s.
  • As a PD caregiver, you can wear this shirt as a show of support for your PD fighter and partner with them through encouragement and participation in living like a warrior.
  • For someone who really wants to help in the fight of Parkinson’s disease, these shirts serve as great conversation starters and allow you to stand up as a voice and engage in meaningful conversations surrounding Parkinson’s disease while providing valuable funds to the APDA for needed research and education.

Regardless of your role, these shirts are meant to encourage you to stand up and live like a warrior each day, and be a new voice for PD wherever you wear them! All proceeds after paying the cost of the shirts will be donated to the Parkinson’s Association of Alabama.

Front of shirt with the Shaking Up LA logo and American flag emblem in the shape of the state of Alabama

 

 

 

Back of shirt with Real Slim Shaky emblem and Each Day is a New Fight real_slim_shaky_shirt_back

 

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